The answer is D. The program prints:
[48, 44, 42, 33, 21, 7]

Why?
sort() puts the list in order, smallest first. reverse=True flips it, so the biggest comes first. It changes the list itself.
The code again
scores = [7, 33, 21, 48, 42, 44]
scores.sort(reverse=True)
print(scores)
Try it: change one number in the program and predict the new output before you run it.